Description
Pharmocological action
Testosterone enantate injection contains the active ingredient testosterone enantate, which is an ester of the naturally occurring male hormone testosterone.
Testosterone is known as an androgen. It is produced by the testicles and is the main hormone essential for normal growth and development of the male sex organs and male sexual characteristics.
The natural production of testosterone is controlled by another set of hormones called gonadotrophins, which are released from the pituitary gland in the brain.
During adult life, testosterone is essential for the production of sperm, the maintenance of sex drive, erectile potency, and the functioning of the prostate gland and other reproductive structures. It also has functions in the skin, muscles, skeleton, kidney, liver, bone marrow and central nervous system.
Low levels of testosterone can cause decreased sex drive, impotence, infertility due to decreased sperm production, decreased mental and physical activity, fatigue and weakening of bones (osteoporosis). Testosterone is given as replacement therapy when natural testosterone levels fall too low, causing problems such as those above.
Natural testosterone levels fall slowly with age and fall rapidly following surgical removal of the testicles (for example in the treatment of testicular cancer).They may also fall due to decreased functioning of the testicles (hypogonadism or eunuchoidism) caused by testicular disease, or by decreased gonadotrophin production by the pituitary gland, as a result of pituitary disease.
Testosterone replacement allows natural testosterone levels to return to normal, thus relieving the symptoms of the deficiency.
Side effects
Medicines and their possible side effects can affect individual people in different ways.The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Reaction at the injection site.
Prostate problems, such as growth of the prostate gland, increased PSA levels and prostate cancer (see warning section above).
Headache.
Feeling sickand vomiting.
Mood changes.
Depression.
Nervousness, anxiety or irritability.
Change in sexdrive.
Breast pain, enlargement of the breasts.
Persistent painful erection of the penis (priapism).Tell your doctor straight away if you experience this.
Decreased sperm count.
Swelling caused byfluid retention (oedema).
Increased blood pressure (hypertension).
Increased levels of red blood cells and haemoglobin in the blood (polycythaemia).
Weight gain.
Pain in the muscle or joints.
Male-pattern hair loss.
Acne.
Itching.
Raised cholesterol levels.
Jaundice.
Livertumours.
Premature sexual development if used in boys who haven’t reached puberty.
Premature closure of the ends of bones, causing stunted growth if used in boys who haven’t reached puberty.
The side effects listed above may not include all of the side effects reported by the medicine’s manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
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