Epoetin Injection is a man-made version of human Erythropoietin (EPO). This hormone is naturally produced in the body by the kidney and it stimulates the bone marrow to produce red blood cells. Lesser quantity up to 10% can be produced by the liver. It is used to treat severe anemia in patients on kidney dialysis or for those not on dialysis. The Erythropoietin (EPO) level can be detected and measured in the blood through an EPO test and the level can be used in detecting some medical conditions. Abnormal level of Erythropoietin (EPO) indicates bone marrow disorder.
If synthesized, can be used to treat some other forms of anemia. Apart from the fact that the hormone Erythropoietin (EPO) regulates the production of red blood cells, another major functions of the hormone is that the synthesis of hemoglobin (the molecule within the red blood cell that transports oxygen) is initiated.
Erythropoietin (EPO) is administered to regulate erythrocyte differentiation and to maintain the level of physiology as erythrocyte mass circulates. For patients treated for increasing autologous blood, administer after blood is donated. For chronic renal failure (CRF) patients on hemodialysis, inject into the venous line at the end the dialysis procedure.
Report says that it increases the reticulocyte count within 10days of initiation, which is followed by the increase in the RBC count, hemoglobin and hematocrit, which is usually in the range of 2 to 6 weeks.
Dosage and Usage
Dissolve powder with full contents of accompanying solvent ampoule. Swirl vial gently until dissolved; do not shake. Solution should be clear, colorless and practically free of particles.
Use a 26 gauge needle to withdraw appropriate amount for a single injection; replace needle before injection.
Recommended Temperature for vials and pre-filled syringes:2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Do not shake. No preservatives in the prefilled syringe. Use 1 dose per syringe. Discard unused portion. A single excursion is permitted at room temperature for up to 3 days. Before reconstitution a single excursion is permitted at room temperature for up to 2 days.
After reconstitution, store at 2°C to 8°C (36°F to 46°F). Discard vial 1 month after initial entry.
Result of Overdose
Excess Erythropoietin (EPO) results in chronic low oxygen levels or from rare tumors that produce high levels of Erythropoietin. The condition known as polycythaemia could occur, which is a high red blood cell count.
Increase blood pressure; joint, muscle and bone pains; fever, chills, cough; sleeplessness; dizziness; nausea; vomiting; Itching or rash; mouth pain; trouble swallowing; headache.