Desyrel (Trazodone) is a triazolopyridine derivative which is used for treatment of depressive disorders, including depression associated with anxiety and sleep disorders, and has a short latency period (about a week).
Desyrel is a serotonin reuptake inhibitor and 5-HT2 receptor antagonist, the activation of which is mainly associated with insomnia, anxiety, agitation and changes in sexual function.
Unlike other psychotropic drugs, Desyrel is not contraindicated in glaucoma, diseases of the urinary tract, does not have extrapyramidal effects, does not potentiate adrenergic transmission; due to the lack of anticholinergic activity, Desyrel does not have the typical cardiac effects of tricyclic antidepressants.
Method of administration and dosage
The tablets should be taken whole without chewing and drinking plenty of water.
Therapy should be started with an evening intake and a gradual increase in daily doses.
The drug can be taken with or without food.
The drug should be taken in cycles of at least one month.
75-150 mg / day as a single dose in the evening before bedtime. The dose can be increased up to 300 mg / day in two divided doses.
In hospitalized patients, the dose may be gradually increased to 600 mg / day in repeated doses.
For elderly or debilitated patients, the recommended daily dose should be reduced to 100 mg / day in divided doses or as a single dose in the evening before bedtime. This dose can be gradually increased under the supervision of a physician, depending on the effectiveness and tolerability of the drug. In most cases, for these patients, a single dose of more than 100 mg should be avoided. A dose exceeding 300 mg / day is usually not required.