Antidepressant. The mechanism of action is associated with the selective inhibition of the reuptake of serotonin by neurons in the brain and is characterized by a minimal effect on noradrenergic transmission. Fluvoxamine has a weak ability to bind to α- and β-adrenergic receptors, histamine, m-cholinergic receptors, dopamine and serotonin receptors.
Method of administration and dosage
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Depression. The recommended starting dose is 50 or 100 mg (once, in the evening). It is recommended to gradually increase the starting dose to the effective level. The effective daily dose, usually 100 mg, is selected individually, depending on the patient’s response to treatment. The daily dose can be as high as 300 mg. Daily doses over 150 mg should be divided into several doses. According to the official WHO guidelines, antidepressant treatment should be continued for at least 6 months of remission after a depressive episode. To prevent relapse of depression, it is recommended to take 100 mg of Faverin 1 time per day.
Obsessive-compulsive disorders. It is recommended to start with a dose of 50 mg Fevarin per day for 3-4 days. An effective daily dose is typically 100 to 300 mg. Doses should be increased gradually until an effective daily dose is reached, which should not exceed 300 mg in adults. Doses up to 150 mg can be taken as single doses, preferably in the evening. Daily doses over 150 mg are recommended to be divided into 2 or 3 doses. Doses for children over 8 years old and adolescents: initial – 25 mg / day for 1 dose, maintenance – 50-200 mg / day. The daily dose should not exceed 200 mg. It is recommended to divide daily doses over 100 mg into 2 or 3 doses. In case of a good response to the drug, treatment can be continued at an individually selected daily dose. If improvement is not achieved after 10 weeks of treatment, fluvoxamine should be discontinued. Until now, systemic studies have not been organized that could answer the question of how long treatment with fluvoxamine can be carried out, however, obsessive-compulsive disorders are chronic, and therefore it can be considered advisable to prolong treatment with Faverin beyond 10 weeks in patients who responded well for this drug. The selection of the minimum effective maintenance dose should be carried out with caution on an individual basis. Some clinicians recommend concomitant psychotherapy in patients who respond well to pharmacotherapy. Treatment of patients with hepatic or renal insufficiency should be started with the lowest doses under strict medical supervision. Due to the lack of clinical experience, Faverin is not recommended for the treatment of depression in children.